Trifluoroacetic acid → HCID 117697565, compound

HRID 1778505Notes

Reaction equation

HRID 1778505 reaction equation
C(OC([N:8]1[C:13]2([C:16]([OH:18])=[O:17])[CH2:14][CH2:15][CH:9]1[CH2:10][O:11][CH2:12]2)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:9]12[NH:8][C:13]([C:16]([OH:18])=[O:17])([CH2:14][CH2:15]1)[CH2:12][O:11][CH2:10]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 1176981981638651-87-2

Product 1

HCID 117697565HCID 117697565, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 8-tert-butoxycarbonyl-3-oxa-8-azabicyclo[3.2.1]octane-5-carboxylic acid (40 mg, 0.15 mmol) in DCM (3 mL) was added TFA (1 mL), The mixture was stirred at room temperature for 4 h. The mixture was concentrated in vacuo to afford 3-oxa-8-azabicyclo[3.2.1]octane-5-carboxylic acid 81a (20 mg, 85%) which was used for next step without further purification. MS: calc'd (MH+) 158, measured (MH+) 158.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-8f74ba7afa00497aba2b56174097c60d
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

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