2-Chloro-4-fluorobenzaldehyde → HCID 131734825, compound

HRID 1778531Notes

Reaction equation

HRID 1778531 reaction equation
ClC1C=C(F)C=CC=1[C@H]1[C:14]([C:15]([O-:17])=[O:16])=[C:13]([CH2:18][Br:19])[NH:12][C:11]([C:20]2[S:21][CH:22]=[CH:23][N:24]=2)=[N:10]1.[F:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][C:33]=1[F:34])[CH:29]=O.Cl[C:36]1C=C(F)C=CC=1C=O>>[Br:19][CH2:18][C:13]1[NH:12][C:11]([C:20]2[S:21][CH:22]=[CH:23][N:24]=2)=[N:10][C@@H:29]([C:28]2[CH:31]=[CH:32][C:33]([F:34])=[C:26]([F:25])[CH:27]=2)[C:14]=1[C:15]([O:17][CH3:36])=[O:16]

Participants

4

Reactant 3

HCID 1450242-Chloro-4-fluorobenzaldehydeHCID 5880883,4-DifluorobenzaldehydeHCID 131734826(4R)-4-(2-chloro-4-fluoro-phenyl)-6-(bromomethyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate

Product 1

HCID 131734825HCID 131734825, compound

Procedure

Methyl (4S)-6-(bromomethyl)-4-(3,4-difluorophenyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 114a was prepared in analogy to compound C with procedures shown in Example 1 by using 3,4-difluoro-benzaldehyde instead of and 2-chloro-4-fluoro-benzaldehyde.

Sources & evidence

ORD record
ord-6cc50c67aef94175910bf778049dcd7b
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

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