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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1778531Generated: November 4, 2026

2-Chloro-4-fluorobenzaldehyde → HCID 131734825, compound

https://huagongshe.com/reaction/1778531

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4-fluorobenzaldehydeHCID 145024—
Reactant3,4-DifluorobenzaldehydeHCID 588088—
Reactant(4R)-4-(2-chloro-4-fluoro-phenyl)-6-(bromomethyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylateHCID 131734826—
ProductHCID 131734825HCID 131734825—

Reaction Steps

Methyl (4S)-6-(bromomethyl)-4-(3,4-difluorophenyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 114a was prepared in analogy to compound C with procedures shown in Example 1 by using 3,4-difluoro-benzaldehyde instead of and 2-chloro-4-fluoro-benzaldehyde.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266904B2
Source datasetuspto-grants-2016_02
ORD IDord-6cc50c67aef94175910bf778049dcd7b
Source noteuspto-grants-2016_02