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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1778547Generated: November 3, 2026

Ethyl Acetoacetate → HCID 131734829, compound

https://huagongshe.com/reaction/1778547

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl AcetoacetateHCID 8868—
Reactant2,3-DifluorobenzaldehydeHCID 137664—
Reactant2-Chloro-4-fluorobenzaldehydeHCID 145024—
Reactant(4R)-4-(2-chloro-4-fluoro-phenyl)-6-(bromomethyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylateHCID 131734826—
ProductHCID 131734829HCID 131734829—

Reaction Steps

Ethyl (4R)-6-(bromomethyl)-4-(2,3-difluoro-phenyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 140a was prepared in analogy to compound C in Example 1 by using ethyl acetoacetate and 2,3-difluorobenzaldehyde instead of methyl acetoacetate and 2-chloro-4-fluoro-benzaldehyde, respectively.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266904B2
Source datasetuspto-grants-2016_02
ORD IDord-6865bf13a3224b0fb6aa14b3b3eb3a84
Source noteuspto-grants-2016_02