HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 6,6-difluoro-8-azabicyclo[3.2.1]octane-3-carboxylate → HCID 117697779, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 6,6-difluoro-8-azabicyclo[3.2.1]octane-3-carboxylate | HCID 117706760 | — |
| Reactant | Ethyl (R)-6-(bromomethyl)-4-(2-chloro-3-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 118358749 | — |
| Product | HCID 117697779 | HCID 117697779 | 6% |
Reaction Steps
The title compound was prepared in analogy to Example 1, by using methyl 6,6-difluoro-8-azabicyclo[3.2.1]octane-3-carboxylate 150a (200 mg) and ethyl (4R)-6-(bromomethyl)-4-(2-chloro-3-fluoro-phenyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 98a (400 mg). 30 mg of the title compound was isolated finally after preparative HPLC purification. Preparation of methyl 6,6-difluoro-8-azabicyclo[3.2.1]octane-3-carboxylate 150a:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266904B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-cecd450ee3424ffa8703e8dfb506d8d2 |
| Source note | uspto-grants-2016_02 |