Trifluoroacetic acid → HCID 178493518, compound

HRID 1778678Notes

Reaction equation

HRID 1778678 reaction equation
C(O)(C(F)(F)F)=O.[F:8][C:9]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[C:11]([F:19])[C:10]=1[C:20]1[N:25]=[C:24]2[NH:26][N:27]=[C:28](I)[C:23]2=[CH:22][N:21]=1.[CH3:30][N:31]([CH3:50])[CH2:32][CH2:33][O:34][C:35]1[CH:40]=[CH:39][C:38](B2OC(C)(C)C(C)(C)O2)=[CH:37][CH:36]=1>>[F:8][C:9]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[C:11]([F:19])[C:10]=1[C:20]1[N:25]=[C:24]2[NH:26][N:27]=[C:28]([C:38]3[CH:39]=[CH:40][C:35]([O:34][CH2:33][CH2:32][N:31]([CH3:50])[CH3:30])=[CH:36][CH:37]=3)[C:23]2=[CH:22][N:21]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 425989244-(2-(Dimethylamino)ethoxy)benzeneboronic acid, pinacol esterHCID 178493522HCID 178493522, compound

Product 1

HCID 178493518HCID 178493518, compound

Procedure

This compound was prepared as TFA salt by using procedures analogous to those described for the synthesis of Example 7, Step 3 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine and N,N-dimethyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethanamine (Combi-Blocks, Cat. No. PN-3972). LCMS (M+H)+=456.1.

Sources & evidence

ORD record
ord-a9f01ddc539f4f73aafdf2ab5f374ea5
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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