Dimethylamine → 2-{4-[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}-N,N-dimethylacetamide

HRID 1778708Notes

Reaction equation

HRID 1778708 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28](O)=[O:29])[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1.[CH3:31][NH:32][CH3:33]>C1COCC1>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([N:32]([CH3:33])[CH3:31])=[O:29])[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 86722827{4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid

Product 1

HCID 762853612-{4-[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}-N,N-dimethylacetamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 36, Step 2, starting from {4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid and 2.0 M dimethylamine in THF. LCMS (M+H)+=475.0/477.0.

Workup

  1. customThis compound was prepared
  2. customthose described for the synthesis of Example 36, Step 2

Sources & evidence

ORD record
ord-069a089ed2af42eab0fce88dfe7c8547
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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