4-Aminotetrahydropyran → 5-bromo-2-(tetrahydro-2H-pyran-4-yl)isoindolin-1-one

HRID 1778746Notes

Reaction equation

HRID 1778746 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O-:8])=O)=[C:4]([CH2:11]Br)[CH:3]=1.[NH2:13][CH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:8])[N:13]([CH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)[CH2:11]2

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 231581454-Bromo-2-(bromomethyl)benzoate

Product 1

HCID 867228435-bromo-2-(tetrahydro-2H-pyran-4-yl)isoindolin-1-one

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 6 starting from 4-bromo-2-(bromomethyl)benzoate (AstaTech Cat. No. 27012) and 4-aminotetrahydropyran (Aldrich Cat No. 711357). LCMS (M+H)+=296.0/298.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-005a41558219478cb26bb7bafc6997b9
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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