1-Amino-2-propanol → 5-Bromo-2-(2-hydroxypropyl)isoindolin-1-one

HRID 1778752Notes

Reaction equation

HRID 1778752 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O-:8])=O)=[C:4]([CH2:11]Br)[CH:3]=1.[NH2:13][CH2:14][CH:15]([OH:17])[CH3:16]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:8])[N:13]([CH2:14][CH:15]([OH:17])[CH3:16])[CH2:11]2

Participants

3

Reactant 2

HCID 41-Amino-2-propanolHCID 231581454-Bromo-2-(bromomethyl)benzoate

Product 1

HCID 867228495-Bromo-2-(2-hydroxypropyl)isoindolin-1-one

Procedure

This compound was prepared using procedures analogous to those described for the synthesis of Example 52, Step 6 starting from 4-bromo-2-(bromomethyl)benzoate and 1-amino-2-propanol (Aldrich Cat No. 110248). LCMS (M+H)+=270.0/272.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-13bb741bae1c456fae182a7d989d5e23
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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