2-(2-Aminoethyl)-1-methylpyrrolidine → 5-Bromo-2-[2-(1-methylpyrrolidin-2-yl)ethyl]isoindolin-1-one

HRID 1778762Notes

Reaction equation

HRID 1778762 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O-:8])=O)=[C:4]([CH2:11]Br)[CH:3]=1.[NH2:13][CH2:14][CH2:15][CH:16]1[CH2:20][CH2:19][CH2:18][N:17]1[CH3:21]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:8])[N:13]([CH2:14][CH2:15][CH:16]1[CH2:20][CH2:19][CH2:18][N:17]1[CH3:21])[CH2:11]2

Participants

3

Reactant 2

HCID 983882-(2-Aminoethyl)-1-methylpyrrolidineHCID 231581454-Bromo-2-(bromomethyl)benzoate

Product 1

HCID 867228585-Bromo-2-[2-(1-methylpyrrolidin-2-yl)ethyl]isoindolin-1-one

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 6 starting from 4-bromo-2-(bromomethyl)benzoate and 2-(2-aminoethyl)-1-methylpyrrolidine (Aldrich Cat No. D139505). LCMS (M+H)+=323.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-7ba706fa21824dbea588cd930f7d6560
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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