Trifluoroacetic acid → HCID 178493470, compound

HRID 1778788Notes

Reaction equation

HRID 1778788 reaction equation
C(O)(C(F)(F)F)=O.[Cl:8][C:9]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[C:11]([Cl:19])[C:10]=1[C:20]1[N:25]=[C:24]2[NH:26][N:27]=[C:28](I)[C:23]2=[CH:22][N:21]=1.[O:30]1[C:34]2[CH:35]=[CH:36][C:37](B(O)O)=[CH:38][C:33]=2[CH2:32][CH2:31]1>>[Cl:8][C:9]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[C:11]([Cl:19])[C:10]=1[C:20]1[N:25]=[C:24]2[NH:26][N:27]=[C:28]([C:37]3[CH:36]=[CH:35][C:34]4[O:30][CH2:31][CH2:32][C:33]=4[CH:38]=3)[C:23]2=[CH:22][N:21]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 2773380(2,3-Dihydro-1-benzofuran-5-yl)boronic acidHCID 178493476HCID 178493476, compound

Product 1

HCID 178493470HCID 178493470, compound

Procedure

This compound was prepared as TFA salt by using procedures analogous to those described for the synthesis of Example 7, Step 3 starting from 6-(2,6-dichloro-3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine and 2,3-dihydro-1-benzofuran-5-ylboronic acid. LCMS (M+H)+=443.0/445.0.

Sources & evidence

ORD record
ord-8dc616876b5e4f62b5d41b2d0b7e542c
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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