反应详情

温度

45 °C

To a suspension of 2b (1.60 g, 4.37 mmol) in absolute ethanol (10 ml) was added 2-pyridinecarboxaldehyde (1.24 ml, 13.11 mmol, 3 eq.) and two drops of formic acid. The mixture was stirred at 45° C. overnight. On cooling to room temperature the suspension was filtered, washed with cold ethanol and dried under reduced pressure to afford 18a as a yellow solid (1.68 g, 49%).

1. temperatureOn cooling to room temperature the suspension
2. filtrationwas filtered
3. washwashed with cold ethanol
4. customdried under reduced pressure