HCID 4305401, compound → HCID 10261979, compound

HRID 1778832Notes

Reaction equation

HRID 1778832 reaction equation
[C:1]1([C:7]2([CH2:12][C:13](OCC)=[O:14])[O:11][CH2:10][CH2:9][O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].C([Al+]CC(C)C)C(C)C>C1(C)C=CC=CC=1>[C:1]1([C:7]2([CH2:12][CH:13]=[O:14])[O:11][CH2:10][CH2:9][O:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 4305401HCID 4305401, compoundHCID 21225700Diisobutylaluminumhydride

Product 1

HCID 10261979HCID 10261979, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of EXAMPLE 65A (2.36 g) in toluene (30 mL) was added diisobutylaluminum hydride (1.5M in toluene, 8 mL) at −78° C. After stirring for 10 minutes the reaction mixture was quenched by addition of water. The precipitate was removed by filtration through diatomaceous earth. The filtrate was washed with water and brine and dried over Na2SO4. Filtration and evaporation of solvent provided the title compound.

Workup

  1. customwas quenched by addition of water
  2. customThe precipitate was removed by filtration through diatomaceous earth
  3. washThe filtrate was washed with water and brine
  4. dry with materialdried over Na2SO4
  5. filtrationFiltration and evaporation of solvent

Sources & evidence

ORD record
ord-cb714939f71a4ddaa51416f2225c9fd1
Source dataset
uspto-grants-2016_02
Patent number
US09266877B2

Reaction notes

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