HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 89497882, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | HCID 89498001 | HCID 89498001 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 89497882 | HCID 89497882 | — |
Reaction Steps
A suspension of EXAMPLE 77C (150 mg), morpholine (0.117 mL), acetic acid (0.062 mL) and solid-supported MP-CNBH3 (Argonaut Technologies, 885 mg, 2.63 mmol/g) in dichloromethane (4 mL) and methanol (2 mL) was shaken at room temperature for 18 hours. The reaction mixture was filtered, concentrated and purified by RP HPLC (30-100% CH3CN/water/0.1% TFA) to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266877B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-b8d09e87e7724498b709557f1737d96f |
| Source note | uspto-grants-2016_02 |