N-Methylaniline → HCID 86681316, compound

HRID 1778881Notes

Reaction equation

HRID 1778881 reaction equation
F[C:2]1[C:7]([CH3:8])=[C:6]([I:9])[CH:5]=[CH:4][N:3]=1.[CH3:10][NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[I:9][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:11]([CH3:10])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 7515N-MethylanilineHCID 117762982-Fluoro-4-iodo-3-methylpyridine

Product 1

HCID 86681316HCID 86681316, compound

Procedure

2-Fluoro-4-iodo-3-methylpyridine (700 mg) in N-methylaniline (2.5 mL) was heated at 18° C. in a Biotage Initiator microwave reactor for 18 hours. The reaction mixture was loaded onto a silica gel cartridge, and was eluted with 0-100% dichloromethane in hexanes to provide the title compound.

Workup

  1. washwas eluted with 0-100% dichloromethane in hexanes

Sources & evidence

ORD record
ord-750e4549fec44817a7a0e62e41b7e283
Source dataset
uspto-grants-2016_02
Patent number
US09266877B2

Reaction notes

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