N-Methylcyclohexylamine → HCID 86681325, compound

HRID 1778906Notes

Reaction equation

HRID 1778906 reaction equation
F[C:2]1[C:7]([CH3:8])=[C:6]([I:9])[CH:5]=[CH:4][N:3]=1.[CH3:10][NH:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>>[CH:12]1([N:11]([CH3:10])[C:2]2[C:7]([CH3:8])=[C:6]([I:9])[CH:5]=[CH:4][N:3]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 7514N-MethylcyclohexylamineHCID 117762982-Fluoro-4-iodo-3-methylpyridine

Product 1

HCID 86681325HCID 86681325, compound

Procedure

2-Fluoro-4-iodo-3-methylpyridine (700 mg) in N-methylcyclohexanamine (2.2 ml) was heated at 180(C in a Biotage Initiator microwave reactor for 18 hours. The reaction mixture was loaded onto a silica gel cartridge, and was eluted with 0-100% dichloromethane in hexanes to provide the title compound.

Workup

  1. washwas eluted with 0-100% dichloromethane in hexanes

Sources & evidence

ORD record
ord-6a1da3f2da554d4297bcfb53b448577c
Source dataset
uspto-grants-2016_02
Patent number
US09266877B2

Reaction notes

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