HCID 89498195, compound → HCID 118106884, compound

HRID 1778937Notes

Reaction equation

HRID 1778937 reaction equation
[CH3:1][C:2]([OH:16])([CH2:10][CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[CH2:3][N:4]1[C:8]([CH3:9])=[CH:7][CH:6]=[N:5]1>C(O)=O>[CH3:9][C:8]1[N:4]([CH2:3][C:2]2([CH3:1])[CH2:10][CH2:11][CH2:12][C:13]([CH3:15])([CH3:14])[O:16]2)[N:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 89498195HCID 89498195, compound

Product 1

HCID 118106884HCID 118106884, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of EXAMPLE 186A (6.5 g) and formic acid (20 mL) was heated at 100° C. for 3 hours. The reaction mixture was concentrated, and the residue was purified by silica gel chromatography, eluting with 1% ethyl acetate in petroleum ether, to give the title product.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by silica gel chromatography
  3. washeluting with 1% ethyl acetate in petroleum ether

Sources & evidence

ORD record
ord-ad6a274bace74fb3b56c7c03287857f6
Source dataset
uspto-grants-2016_02
Patent number
US09266877B2

Reaction notes

Loading…