反应详情

2-Oxo-2-phenyl-ethyl (S)-2-tert-butoxycarbonylamino-3-(4-but-2-ynyloxy-phenyl)-propionate (275 mg) was dissolved in methylene chloride (5.0 mL), and trifluoroacetic acid (1.0 mL) was added. The mixture was reacted with stirring for 30 minutes. After completing the reaction, the solvent was distilled off under reduced pressure. An appropriate amount (ca. 5 mL) of toluene was added and the mixture was concentrated in vacuo three times (azeotropic distillation) to obtain 290 mg of the target compound (LCMS m/z 352 (M+1) Rt 1.38 min.).

1. customThe mixture was reacted
2. customthe reaction
3. distillationthe solvent was distilled off under reduced pressure
4. additionAn appropriate amount (ca. 5 mL) of toluene was added
5. concentrationthe mixture was concentrated in vacuo three times (azeotropic distillation)