Hydrogen chloride-ethyl acetate → HCID 131734860, compound

HRID 1779196Notes

Reaction equation

HRID 1779196 reaction equation
C(OC([NH:8][C@@H:9]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]#[C:28][CH3:29])=[CH:21][CH:20]=1)[C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])=O)(C)(C)C.[ClH:30].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:30].[NH2:8][C@@H:9]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]#[C:28][CH3:29])=[CH:21][CH:20]=1)[C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 118263479HCID 118263479, compound

Product 1

HCID 131734860HCID 131734860, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Methyl [(S)-2-tert-butoxycarbonylamino-3-(4-but-2-ynyloxy-phenyl)-propionylamino]-acetate (141 mg, 0.349 mmol) was dissolved in ethyl acetate (2.0 mL), and 4 M hydrogen chloride/ethyl acetate (0.2 mL) was added. The mixture was stirred at room temperature for 18 hours.

Sources & evidence

ORD record
ord-7266883a18384f01949e4becd1dd8630
Source dataset
uspto-grants-2016_02
Patent number
US09266853B2

Reaction notes

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