Tetrahydrofuran → HCID 23666951, compound

HRID 1779301Notes

Reaction equation

HRID 1779301 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[C:9](=[O:10])[O:8][C:7]2([OH:22])[C:12]1[N:17]=[C:16]([O:18][CH3:19])[CH:15]=[C:14]([O:20][CH3:21])[N:13]=1.[OH-].[Na+:24].C1COCC1>O>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([C:7]([C:12]2[N:13]=[C:14]([O:20][CH3:21])[CH:15]=[C:16]([O:18][CH3:19])[N:17]=2)=[O:22])[C:11]=1[C:9]([O-:10])=[O:8].[Na+:24]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 19050642HCID 19050642, compound

Product 1

HCID 23666951HCID 23666951, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.24 g of 7-chloro-3-hydroxy-3-(4,6-dimethoxy-2-pyrimidinyl)phthalide, 154 mg NaOH, 25 ml THF and 25 ml water are mixed until a yellow homogenous solution is achieved. The solvents are stripped on a rotovaporator and then on a Kugelrohr at 100° C. to produce the title compound as a yellow solid, m.p. 276°-278° C.

Sources & evidence

ORD record
ord-be6a4e30ba9d4a19a37fb7b644ca66f1
Source dataset
uspto-grants-1997_05
Patent number
US05627137

Reaction notes

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