HCID 19955645, compound → HCID 707375, compound

HRID 1779364Notes

Reaction equation

HRID 1779364 reaction equation
[C:1]1([C:7]2[CH:16]=[C:15]([C:17]([O:19]C)=[O:18])[C:14]3[C:9](=[C:10]([O:21][CH3:22])[CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C1COCC1>[C:1]1([C:7]2[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]3[C:9](=[C:10]([O:21][CH3:22])[CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 19955645HCID 19955645, compound

Product 1

HCID 707375HCID 707375, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

An anhydrous THF (50 ml) solution containing 4.0 g of methyl 2-phenyl-8-methoxyquinoline-4-carboxylate formed from 2-phenyl-8-methoxyquinoline-4-carboxylic acid in a usual manner was added to guanidine formed from 6.50 g of guanidine hydrochloride in the same manner as in [C] of Example 1 at room temperature. Subsequently, the mixture was heat-refluxed for 3 hours, and cooled to room temperature. The reaction mixture was then concentrated under reduced pressure, and ice water was added to the residue. The precipitate formed was collected by filtration, washed with ethyl ether, and dried to obtain 3.59 of the above-mentioned compound as a white crystal. m.p. 232°-235° C. (decomp.)

Sources & evidence

ORD record
ord-b37e0875b1084782a861398d2c6fe8b3
Source dataset
uspto-grants-1997_05
Patent number
US05627193

Reaction notes

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