Diethyl Ether → HCID 178438923, compound

HRID 1779368Notes

Reaction equation

HRID 1779368 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:19]=[C:18]([C:20]([NH:22][C:23]([NH2:25])=[NH:24])=[O:21])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1)([CH3:3])[CH3:2].[CH3:26][S:27]([OH:30])(=[O:29])=[O:28].C(OCC)C>C(O)C>[CH3:26][S:27]([OH:30])(=[O:29])=[O:28].[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:19]=[C:18]([C:20]([NH:22][C:23]([NH2:25])=[NH:24])=[O:21])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 6395Methanesulfonic AcidHCID 178438922HCID 178438922, compound

Product 1

HCID 178438923HCID 178438923, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

2-(2'-Isopropylphenyl)quinoline-4-carbonylguanidine (1.1 g) formed in Example 5 was suspended in 25 ml of ethanol, and 7.5 ml (1M) of an ethanol solution of methanesulfonic acid were added thereto dropwise while being cooled with ice. Ten minutes later, ethyl ether was added thereto, and the crystals precipitated were collected by filtration, and dried to obtain 1.10 g of the above-mentioned compound as a white crystal. m.p. 146°-154° C.

Workup

  1. temperaturedropwise while being cooled with ice
  2. customthe crystals precipitated
  3. filtrationwere collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-1a5c1f824ff549cf8315dc42b6a60865
Source dataset
uspto-grants-1997_05
Patent number
US05627193

Reaction notes

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