反应详情

Add 5 g of 2-aminoxy-1-bromoethane hydrobromide, 1.5 mol of glacial acetic acid and 1.6 ml of pyridine in succession to a suspension of 1.43 g of 3-methyl-8H-thieno[2,3-d]pyrrolo[1,2-a]pyrrol-2-one (Preparation 29) in 70 ml of ethanol. The reaction mixture is heated at reflux for 3 hours, then the ethanol is removed under reduced pressure and the residue is extracted with 100 ml of diethyl ether. After washing with water, drying, concentrating to dryness and working up again in a diethyl ether/petroleum ether mixture, 1:1, the title compound is obtained in the form of a powder.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 3 hours
3. customthe ethanol is removed under reduced pressure
4. extractionthe residue is extracted with 100 ml of diethyl ether
5. washAfter washing with water
6. customdrying
7. concentrationconcentrating to dryness