Acetic Acid → HCID 19956208, compound

Participants

Reaction Steps

Add 5 g of 2-aminoxy-1-bromoethane hydrobromide, 1.5 mol of glacial acetic acid and 1.6 ml of pyridine in succession to a suspension of 1.43 g of 3-methyl-8H-thieno[2,3-d]pyrrolo[1,2-a]pyrrol-2-one (Preparation 29) in 70 ml of ethanol. The reaction mixture is heated at reflux for 3 hours, then the ethanol is removed under reduced pressure and the residue is extracted with 100 ml of diethyl ether. After washing with water, drying, concentrating to dryness and working up again in a diethyl ether/petroleum ether mixture, 1:1, the title compound is obtained in the form of a powder.

Provenance & Evidence