反应详情

Under cooling on ice, 70 ml HCl-methanol was added to 70 ml of 9.47 g (30.35 mmol) 5,7-bis(methoxymethoxy)-2-methylthiochromone in THF. The mixture was stirred overnight at room temperature. Subsequently, water was added to the solution thus reacted. The product was extracted twice with ethyl acetate, and the organic layer was washed with brine and dried over anhydrous sodium sulfate. The solvent was distilled out under reduced pressure, whereby 6.88 g of 5,7-dihydroxy-2-methylthiochromone was obtained. This product was used without being purified in the following reaction.

1. customthus reacted
2. extractionThe product was extracted twice with ethyl acetate
3. washthe organic layer was washed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. distillationThe solvent was distilled out under reduced pressure