Hydrochloric Acid → HCID 19956395, compound

HRID 1779531Notes

Reaction equation

[CH2:1]([N:4](C(OC(C)(C)C)=O)[CH2:5][CH2:6][CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9]/[CH:10]=[CH:11]/[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][CH2:15][CH2:16][N:17]([CH2:25][C:26]#[CH:27])C(OC(C)(C)C)=O)[C:2]#[CH:3].[ClH:49]>>[ClH:49].[ClH:49].[ClH:49].[ClH:49].[CH2:25]([NH:17][CH2:16][CH2:15][CH2:14][NH:13][CH2:12]/[CH:11]=[CH:10]/[CH2:9][NH:8][CH2:7][CH2:6][CH2:5][NH:4][CH2:1][C:2]#[CH:3])[C:26]#[CH:27]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19956398HCID 19956398, compound

Product 1

HCID 19956395HCID 19956395, compound

Procedure

0.97 g (1.43 mmol) of (E)-1,14-di-propargyl-1,5,10,14-tetra-BOC-1,5,10,14-tetraazatetradec-7-ene and 15 ml of 3N methanolic hydrochloric acid are reacted analogously to Example 1. Recrystallisation of the crude product from methanol/water yields the title compound, m.p. >260° C. 1H-NMR (D2O): δ2.07-2.19(m,4H); 3.01(t,2H); 3.15-3.30(m,8H); 3.77(d,4H); 3.96(d,4H); 6.05-6.07(m,2H).

Workup

customRecrystallisation of the crude product from methanol/water

Sources & evidence

ORD record: ord-5aa7f6719473425c9ecf6ebf3169fe2f
Source dataset: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05627215

Reaction notes

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