Hydrochloric Acid → HCID 22015055, compound

HRID 1779542Notes

Reaction equation

HRID 1779542 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][CH2:6][N:5]([CH2:9]/[CH:10]=[CH:11]/[CH2:12][N:13]2[CH2:18][CH2:17][CH2:16][N:15]([CH2:19][CH3:20])C2)C1)[CH3:2].[ClH:21]>CO>[ClH:21].[ClH:21].[ClH:21].[ClH:21].[CH2:19]([NH:15][CH2:16][CH2:17][CH2:18][NH:13][CH2:12]/[CH:11]=[CH:10]/[CH2:9][NH:5][CH2:6][CH2:7][CH2:8][NH:3][CH2:1][CH3:2])[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19956417HCID 19956417, compound

Product 1

HCID 22015055HCID 22015055, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A mixture of 0.18 g (0.642 mmol) of (E)-1,4-bis(3-ethyl-hexahydropyrimidin-1-yl)but-2-ene, 2.5 ml of methanol and 2.56 ml (5.12 mmol) of 2N hydrochloric acid is heated for 72 h under reflux. The reaction mixture is then cooled to room temperature, and 10 ml of methanol are added, whereupon the title compound precipitates in crystalline form. The crystallisate, which is washed with methanol and diethyl ether and dried under a high vacuum at 120° C., melts at >260° C. 1H-NMR (D2O): δ1.27(t,6H); 2.04-2.15(m,4H); 3.07-3.18(m,12H); 3.77(d,4H); 6.04-6.06(m,2H).

Workup

  1. temperatureis heated for 72 h
  2. temperatureunder reflux

Sources & evidence

ORD record
ord-8ba699651af845b3a56600722c43c73d
Source dataset
uspto-grants-1997_05
Patent number
US05627215

Reaction notes

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