Hydrochloric Acid → HCID 19956409, compound

HRID 1779544Notes

Reaction equation

[CH2:1]([N:4](C(OC(C)(C)C)=O)[CH2:5][CH2:6][CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9]/[CH:10]=[CH:11]/[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][CH2:15][CH2:16][N:17]([CH2:25][C:26]#[CH:27])C(OC(C)(C)C)=O)[CH:2]=[CH2:3].[ClH:49]>>[ClH:49].[ClH:49].[ClH:49].[ClH:49].[CH2:1]([NH:4][CH2:5][CH2:6][CH2:7][NH:8][CH2:9]/[CH:10]=[CH:11]/[CH2:12][NH:13][CH2:14][CH2:15][CH2:16][NH:17][CH2:25][C:26]#[CH:27])[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19956384HCID 19956384, compound

Product 1

HCID 19956409HCID 19956409, compound

Procedure

A mixture of 0.22 g (0.324 mmol) of (E)-1-allyl-14-propargyl-1,5,10,14-tetra-BOC-1,5,10,14-tetraazatetradec-7-ene and 3.3 ml of 3N methanolic hydrochloric acid is reacted analogously to Example 8. The resulting title compound melts at >260° C. 1H-NMR (D2O): δ2.07-2.19(m,4H); 3.02(t,1H); 3.08-3.34(m,8H); 3.69(d,2H); 3.77(d,4H); 3.96(d,2H); 5.48-5.55(m,2H); 5.84-5.97(m,1H); 6.04-6.07(m,2H).

Workup

customis reacted analogously to Example 8

Sources & evidence

ORD record: ord-123b90863458430dbfed175ebd60b060
Source dataset: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05627215

Reaction notes

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