Hydrochloric Acid → HCID 19956390, compound

HRID 1779550Notes

Reaction equation

HRID 1779550 reaction equation
[CH:1]([N:4](C(OC(C)(C)C)=O)[CH2:5][CH2:6][CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9]/[CH:10]=[CH:11]/[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][CH2:15][CH2:16][N:17]([CH2:25][CH2:26][CH3:27])C(OC(C)(C)C)=O)([CH3:3])[CH3:2].[ClH:49]>C(OCC)C>[ClH:49].[ClH:49].[ClH:49].[ClH:49].[CH:1]([NH:4][CH2:5][CH2:6][CH2:7][NH:8][CH2:9]/[CH:10]=[CH:11]/[CH2:12][NH:13][CH2:14][CH2:15][CH2:16][NH:17][CH2:25][CH2:26][CH3:27])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19956416HCID 19956416, compound

Product 1

HCID 19956390HCID 19956390, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 0.24 g (0.35 mmol) of (E)-1-isopropyl-14-propyl-1,5,10,14-tetra-BOC-1,5,10,14-tetraazatetradec-7-ene and 4 ml of 3N methanolic hydrochloric acid is stirred for 4 h at room temperature. Then the reaction mixture is diluted with 6 ml of diethyl ether and is worked up analogously to Example 1. The resulting title compound melts at >260° C. 1H-NMR (D2O): δ0.97(t,3H); 1.32(d,6H); 1.63-1.76(m,2H); 2.04-2.17(m,4H); 3.02(t,2H); 3.12-3.19(m,8H); 3.37-3.49(m,1H); 3.78(d,4H); 6.05-6.07(m,2H).

Sources & evidence

ORD record
ord-3e8f72dfb1164facbef59cda8663fce2
Source dataset
uspto-grants-1997_05
Patent number
US05627215

Reaction notes

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