Hydrochloric Acid → HCID 19956426, compound

HRID 1779552Notes

Reaction equation

HRID 1779552 reaction equation
[CH:1]1([CH2:4][N:5](C(OC(C)(C)C)=O)[CH2:6][CH2:7][CH2:8][N:9](C(OC(C)(C)C)=O)[CH2:10]/[CH:11]=[CH:12]/[CH2:13][N:14](C(OC(C)(C)C)=O)[CH2:15][CH2:16][CH2:17][N:18]([CH2:26][CH:27]2[CH2:29][CH2:28]2)C(OC(C)(C)C)=O)[CH2:3][CH2:2]1.[ClH:51]>C(OCC)C>[ClH:51].[ClH:51].[ClH:51].[ClH:51].[CH:27]1([CH2:26][NH:18][CH2:17][CH2:16][CH2:15][NH:14][CH2:13]/[CH:12]=[CH:11]/[CH2:10][NH:9][CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH:1]2[CH2:3][CH2:2]2)[CH2:28][CH2:29]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67648377HCID 67648377, compound

Product 1

HCID 19956426HCID 19956426, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 1.5 g (2.116 mmol) of (E)-1,14-di-cyclopropylmethyl-1,5,10,14-tetra-BOC-1,5,10,14-tetraazatetradec-7-ene and 23 ml of 3N methanolic hydrochloric acid is stirred for 5 h at room temperature, and then 20 ml of diethyl ether are added. Working up analogously to Example 1 yields the title compound, m.p. >260° C. 1H-NMR (D2O): δ0.33-0.38(m,4H); 0.65-0.71 (m,4H); 1.00-1.14(m,2H); 2.05-2.16(m,4H); 2.96(d,4H); 3.13-3.19(m,8H); 3.77(d,4H); 6.04-6.07(m,2H).

Sources & evidence

ORD record
ord-a2f7cdf2cef8487d82aca1ce4912eddb
Source dataset
uspto-grants-1997_05
Patent number
US05627215

Reaction notes

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