Hydrochloric Acid → HCID 15790184, compound

HRID 1779708Notes

Reaction equation

HRID 1779708 reaction equation
Cl.C(Cl)Cl.[CH3:5][C:6]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16](=[N:20][OH:21])[C:17]([NH2:19])=[O:18].O>C1(C)C=CC=CC=1>[CH3:5][C:6]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1/[C:16](=[N:20]\[OH:21])/[C:17]([NH2:19])=[O:18]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6344DichloromethaneHCID 85447596HCID 85447596, compound

Product 1

HCID 15790184HCID 15790184, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Conc. hydrochloric acid (2 ml) and methylene chloride (5 ml) were added to 2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2-hydroxyiminoacetamide (Z=at least 98%) (0.50 g, 1.68 mmol), and the mixture was stirred at room temperature for 15 hours. After stirring, water (5 ml) and toluene (5 ml) were added. The resulting crystals were separated by filtration and dried to give (E)-2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2-hydroxyiminoacetamide (0.48 g, Yield: 96.0%) as colorless crystals.

Workup

  1. stirringAfter stirring
  2. customThe resulting crystals were separated by filtration
  3. customdried

Sources & evidence

ORD record
ord-ba7485cdf9a7463e82f359f3c4c90eed
Source dataset
uspto-grants-1997_05
Patent number
US05627284

Reaction notes

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