Hydrochloric Acid → HCID 76309304, compound

HRID 1779712Notes

Reaction equation

HRID 1779712 reaction equation
C1(C)C=CC=CC=1.Cl.[O:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22](=[N:26][O:27][CH3:28])[C:23]([NH2:25])=[O:24])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>O>[O:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1/[C:22](=[N:26]\[O:27][CH3:28])/[C:23]([NH2:25])=[O:24])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 539671372-(2-Phenoxyphenyl)-2-methoxyiminoacetamide

Product 1

HCID 76309304HCID 76309304, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Toluene (26 ml) and conc. hydrochloric acid (1.1 ml) were added to 2-(2-phenoxyphenyl)-2-methoxyiminoacetamide (E/Z=6/94) (3.48 g, 0.013 mol), and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, water (80 ml) was added. The mixture was extracted with ether (80 ml), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane) to give (E)-2-(2-phenoxyphenyl)-2-methoxyiminoacetamide (3.25 g, Yield: 93.4%).

Workup

  1. additionwas added
  2. extractionThe mixture was extracted with ether (80 ml)
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane)

Sources & evidence

ORD record
ord-e6e8206089684723bdd4417db4e24118
Source dataset
uspto-grants-1997_05
Patent number
US05627284

Reaction notes

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