HRID1779843

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8000

Ethane, 1,1'-oxybis-, compd. with trifluoroborane (1:1)

C4H10BF3O

结构：C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

HCID221493

Cholic acid

C24H40O5

PRODUCTS

生成物

结构：COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

HCID10960835

(3alpha,5beta,7alpha,12alpha)-Cholan-24-oic acid methyl ester

C25H42O5

收率 95%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of cholic acid (300 g, 0.73 mol) in 1.1 L methanol is added boron trifloride etherate. The mixture is refluxed for 1 h. After cooling, a solid precipitate 2 is collected by filtration. The mother liquor is kept in a refrigerator to give another crop of product The combined product (295 g, 95%) is dried under vacuum and used for the next reaction without further purification.

WORKUP

后处理

temperatureThe mixture is refluxed for 1 h
temperatureAfter cooling
filtrationa solid precipitate 2 is collected by filtration