Boron trifluoride etherate → Methyl cholate

関与物質

反応手順

To a solution of cholic acid (300 g, 0.73 mol) in 1.1 L methanol is added boron trifloride etherate. The mixture is refluxed for 1 h. After cooling, a solid precipitate 2 is collected by filtration. The mother liquor is kept in a refrigerator to give another crop of product The combined product (295 g, 95%) is dried under vacuum and used for the next reaction without further purification.

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