Sodium Methoxide → HCID 22872541, compound

HRID 1779943Notes

Reaction equation

HRID 1779943 reaction equation
[C:1]([O:4][C@H:5]1[CH2:31][CH2:30][C@@:29]2([CH3:32])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:28]2[C@H:27]([O:33][C:34](=[O:36])[CH3:35])[C:26](=[O:37])[C@@:25]2([CH3:38])[C@H:11]3[CH2:12][C@@H:13]3[O:18][C@@:17]4([O:24][CH2:23][C@H:21]([CH3:22])[CH2:20][CH2:19]4)[C@@H:15]([CH3:16])[C@@H:14]32)[CH2:6]1)(=[O:3])[CH3:2].C[C@@H]1[C@]2(OC[C@H](C)CC2)O[C@H]2C[C@@H]3[C@@](C)([C@@H]12)C(=O)[C@@H](O)[C@H]1[C@H]3CC[C@@H]2[C@]1(C)CC[C@H](O)C2.C[O-].[Na+]>CO.C1COCC1>[C:1]([O:4][C@H:5]1[CH2:31][CH2:30][C@@:29]2([CH3:32])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:28]2[C@H:27]([O:33][C:34](=[O:36])[CH3:35])[C:26](=[O:37])[C@@:25]2([CH3:38])[C@H:11]3[CH2:12][C@@H:13]3[O:18][C@@:17]4([O:24][CH2:23][C@H:21]([CH3:22])[CH2:20][CH2:19]4)[C@@H:15]([CH3:16])[C@@H:14]32)[CH2:6]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 10942334Sodium MethoxideHCID 131720011HCID 131720011, compound

Product 1

HCID 22872541HCID 22872541, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

(3β,5α,11α,25R)spirostan-3,11-diol-12-one (3β,5α,11α,25R)-3,11-di(acetoxy)spirostan-12-one was saponified with sodium methoxide in methanol and THF to give the title compound.

Sources & evidence

ORD record
ord-08da00e3ab9e4f5895e5eb1cbb7e89bc
Source dataset
uspto-grants-1997_05
Patent number
US05629295

Reaction notes

Loading…