Methanol → HCID 54124296, compound

HRID 1779963Notes

Reaction equation

HRID 1779963 reaction equation
S(Cl)(Cl)=O.[CH3:5][O:6][C:7]1[CH:16]=[C:15]2[C:10]([CH2:11][CH2:12][CH:13]([CH2:18][C:19]([OH:21])=[O:20])[C:14]2=[O:17])=[CH:9][CH:8]=1.[CH3:22]O>>[CH3:5][O:6][C:7]1[CH:16]=[C:15]2[C:10]([CH2:11][CH2:12][CH:13]([CH2:18][C:19]([O:21][CH3:22])=[O:20])[C:14]2=[O:17])=[CH:9][CH:8]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 14737528HCID 14737528, compound

Product 1

HCID 54124296HCID 54124296, compound

Procedure

Under cooling, 1.8 ml of thionyl chloride was dropwise added slowly to 20 ml of methanol. After 10 minutes, 1.5 g of 7-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-acetic acid was added and stirred overnight at room temperature. The solvent was distilled off under reduced pressure to obtain 1.6 g of methyl 7-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-acetate.

Workup

  1. temperatureUnder cooling
  2. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-607ab643cafe42449ff68db610af9941
Source dataset
uspto-grants-1997_05
Patent number
US05629321

Reaction notes

Loading…