Ammonia → HCID 178479083, compound

HRID 1779991Notes

Reaction equation

HRID 1779991 reaction equation
[ClH:1].[NH:2]=[C:3]1[CH2:7][CH2:6][C@@H:5]([CH2:8][O:9]C(=O)C)[NH:4]1.N>CO>[ClH:1].[NH:2]=[C:3]1[CH2:7][CH2:6][C@@H:5]([CH2:8][OH:9])[NH:4]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178476340HCID 178476340, compound

Product 1

HCID 178479083HCID 178479083, compoundYield 51.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 15 mg (0.078 mmol) of 2-imino-5-(S)-acetyloxymethylpyrrolidine hydrochloride prepared in example 7 in 3 mL of methanol was saturated with NH3 and the solution was stirred for 3 h. The reaction mixture was concentrated and the residual solid was suspended in Et2O-EtOAc, filtered and washed with Et2O and dried to isolate 6 mg of the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. filtrationfiltered
  3. washwashed with Et2O
  4. customdried

Sources & evidence

ORD record
ord-b3f31e3bbdd74f68bb8a31d020217044
Source dataset
uspto-grants-1997_05
Patent number
US05629322

Reaction notes

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