Potassium Carbonate → HCID 54349857, compound

HRID 1780005Notes

Reaction equation

HRID 1780005 reaction equation
[CH3:1][C:2]([NH:11][C:12](=[O:21])[C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([Cl:20])[CH:14]=1)([CH3:10])[C:3]([CH2:5][O:6]C(=O)C)=[O:4].C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:10][C:2]([NH:11][C:12](=[O:21])[C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([Cl:20])[CH:14]=1)([CH3:1])[C:3]([CH2:5][OH:6])=[O:4]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 53897658HCID 53897658, compound

Product 1

HCID 54349857HCID 54349857, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(1',1'-dimethyl-3'-acetoxyacetonyl)-3,5-dichlorobenzamide (5.0 gm, 0.15 m) was treated with potassium carbonate (0.21 gm, 0.0015 m) in 250 ml methanol at room temperature for 12 hours. The methanol was removed by a vacuum, the residue was taken up in ether and washed successively with saturated sodium bicarbonate, water and brine. Drying of the ether solution followed by removing the solvent yielded 4.0 gm (98%) of pure product.

Workup

  1. customThe methanol was removed by a vacuum
  2. washwashed successively with saturated sodium bicarbonate, water and brine
  3. dry with materialDrying of the ether solution
  4. customby removing the solvent

Sources & evidence

ORD record
ord-007253616b184568b6a3b6c3cad2d9d0
Source dataset
uspto-grants-1997_05
Patent number
US05629346

Reaction notes

Loading…