3-Chlorophenylacetic acid → 2-(3-chlorophenyl)acetyl Chloride

HRID 1780037Notes

Reaction equation

HRID 1780037 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:14])=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([Cl:14])=[O:11])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 158793-Chlorophenylacetic acidHCID 24386Thionyl Chloride

Product 1

HCID 106552492-(3-chlorophenyl)acetyl Chloride

Procedure

To 3-chlorophenylacetic acid (51 g) was added thionyl chloride (100 ml) and N,N-dimethylforraamide (50 μl). After stirring at room temperature for 18 hours, the thionyl chloride was evaporated at reduced pressure. The residue was dissolved in toluene (60 ml) and again evaporated at reduced pressure to give 3-chlorophenylacetylchloride.

Workup

  1. customthe thionyl chloride was evaporated at reduced pressure
  2. dissolutionThe residue was dissolved in toluene (60 ml)
  3. customagain evaporated at reduced pressure

Sources & evidence

ORD record
ord-a92978df10534fe5a6ca75ea50e1987d
Source dataset
uspto-grants-1997_05
Patent number
US05629347

Reaction notes

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