反应详情

0.78 g (2.50 mmol) of 3-chloro-5-hydroxy-2-(4-octyloxyphenyl)pyridine, 0.52 g (2.50 mmol) of dicyclohexylcarbodiimide, 0.50 g (2.50 mmol) of trans-4-pentylcyclohexanecarboxylic acid and 0.01 g of 4-(N,N-dimethylamino)-pyridine are stirred at room temperature for 18 hours in 20 ml of dichloromethane. Filtration, evaporation to dryness and chromatographic purification (silica gel/ hexane:ethyl acetate 8:2) and recrystallization from acetonitrile give 0.28 g of 3-chloro-2-(4-octyloxyphenyl)pyridin-5-yl trans-4-pentylcyclohexanecarboxylate. ##STR26##

1. filtrationFiltration, evaporation
2. customto dryness and chromatographic purification (silica gel/ hexane:ethyl acetate 8:2) and recrystallization from acetonitrile