Acetate → N-{4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-yl}-acetamide

HRID 178018Notes

Reaction equation

HRID 178018 reaction equation
[Br:17][c:18]1[cH:19][c:20]([C:24]2([CH3:27])[CH2:25][CH2:26]2)[n:21][cH:22][cH:23]1.[C:11](=[O:12])([O-:13])[O-:14].[C:1]([CH3:2])(=[O:3])[NH:4][c:5]1[s:6][cH:7][c:8]([CH3:10])[n:9]1.[Cs+:15].[Cs+:16].[O-:34][C:35]([CH3:36])=[O:37].[O-:38][C:39]([CH3:40])=[O:41].[O:28]=[CH:29][N:30]([CH3:31])[CH3:32].[Pd+2:33]>>[C:1]([CH3:2])(=[O:3])[NH:4][c:5]1[s:6][c:7](-[c:18]2[cH:19][c:20]([C:24]3([CH3:27])[CH2:25][CH2:26]3)[n:21][cH:22][cH:23]2)[c:8]([CH3:10])[n:9]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 280907N-(4-Methylthiazol-2-yl)acetamideHCID 574170884-Bromo-2-(1-methylcyclopropyl)pyridine

Product 1

HCID 86631917N-{4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-yl}-acetamide

Sources & evidence

ORD record
ord-56fe786c1c6e40938239dff625f49725
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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