反应详情

The product of Example 2 (837 g, 2.6M) methanol (1.5 l) and 40% aq. NaOH (1 l, 10M) were heated to reflux for 2 hours. The reaction was then cooled to room temperature and acidified with conc. HCl (1l). The reaction was left as room temperature overnight and then extracted with methyl tert.butyl ether (1 l,500 ml). The extracts were washed with aq. Na2CO3, dried and evaporated to give the title compound(376 g, 89%).

1. temperatureto reflux for 2 hours
2. extractionextracted with methyl tert.butyl ether (1 l,500 ml)
3. washThe extracts were washed with aq. Na2CO3
4. customdried
5. customevaporated