Lithium Hydroxide → HCID 23666946, compound

HRID 1780248Notes

Reaction equation

HRID 1780248 reaction equation
[OH-].[Li+:2].[CH3:3][N:4]([C:6]1[CH:18]=[CH:17][C:9]([O:10][CH2:11][C:12]([O:14]CC)=[O:13])=[CH:8][CH:7]=1)[CH3:5]>CO>[CH3:5][N:4]([C:6]1[CH:18]=[CH:17][C:9]([O:10][CH2:11][C:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)[CH3:3].[Li+:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 19049814HCID 19049814, compound

Product 1

HCID 23666946HCID 23666946, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.15 ml of a 1N aqueous solution of lithium hydroxide was added to a solution of 30 mg (0.13 mmol) of ethyl 4-(N,N-dimethylamino)phenoxyacetate (prepared as described in Preparation 18) in 1 ml of methanol, and the mixture was stirred at room temperature for 1 hour. At the end of this time, the solvent was removed by distillation under reduced pressure, the resulting residue was mixed with benzene and the mixture was dehydrated by azeotropic distillation. This operation was repeated a further time, and then the residue was dried in vacuo for 2 hours, to give 26 mg of lithium 4-(N,N-dimethylamino)phenoxyacetate.

Workup

  1. customAt the end of this time, the solvent was removed by distillation under reduced pressure
  2. additionthe resulting residue was mixed with benzene
  3. distillationthe mixture was dehydrated by azeotropic distillation
  4. customthe residue was dried in vacuo for 2 hours

Sources & evidence

ORD record
ord-613476bbe80c49658a4639418397bd21
Source dataset
uspto-grants-1997_05
Patent number
US05629406

Reaction notes

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