Dimethylamine → HCID 86750821, compound

HRID 1780250Notes

Reaction equation

Br[CH2:2][C:3]([N:5]([C:7]1[CH:49]=[CH:48][C:10]([O:11][CH2:12][C:13]([NH:15][C@H:16]([C:21]([NH:23][C@@H:24]([CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C@H:25]([OH:40])[C:26]([N:28]2[CH2:39][CH2:38][CH2:37][C@H:29]2[C:30]([NH:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])=[O:27])=[O:22])[CH2:17][C:18](=[O:20])[NH2:19])=[O:14])=[CH:9][CH:8]=1)[CH3:6])=[O:4].[CH3:50][NH:51][CH3:52]>>[CH3:50][N:51]([CH2:2][C:3]([N:5]([C:7]1[CH:49]=[CH:48][C:10]([O:11][CH2:12][C:13]([NH:15][C@H:16]([C:21]([NH:23][C@@H:24]([CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C@H:25]([OH:40])[C:26]([N:28]2[CH2:39][CH2:38][CH2:37][C@H:29]2[C:30]([NH:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])=[O:27])=[O:22])[CH2:17][C:18](=[O:20])[NH2:19])=[O:14])=[CH:9][CH:8]=1)[CH3:6])=[O:4])[CH3:52]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 70049329HCID 70049329, compound

Product 1

HCID 86750821HCID 86750821, compoundYield 97.5%

Procedure

Following a procedure similar to that described in Example 38, but using 100 mg (0.13 mmol) of 1-[(2S,3S)-3-{N2 -[4-(N-bromoacetyl-N-methylamino)phenoxy]acetyl-L-asparaginyl}amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide (prepared as described in Example 30) and 0.12 ml (1.3 mmol) of dimethylamine, 90 mg of the title compound were obtained as a colorless powder, melting at 129°-135° C.

Sources & evidence

ORD record: ord-0354fbbf6e194f56bdf5af9b275a7c3a
Source dataset: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05629406

Reaction notes

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