Dimethylamine → HCID 86750821, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 38, but using 100 mg (0.13 mmol) of 1-[(2S,3S)-3-{N2 -[4-(N-bromoacetyl-N-methylamino)phenoxy]acetyl-L-asparaginyl}amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide (prepared as described in Example 30) and 0.12 ml (1.3 mmol) of dimethylamine, 90 mg of the title compound were obtained as a colorless powder, melting at 129°-135° C.

Provenance & Evidence