HRID1780251

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18957386

未命名化合物

结构：CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(N)=O.Cl

HCID67722782

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)COc1cccc(NC(=O)OCc2ccccc2)c1

HCID86750822

未命名化合物

收率 50.2%

PROCEDURE

实验过程

Following a procedure similar to that described in Example 14, but using 0.45 g (0.91 mmol) of 1-[(2S,3S)-3-L-asparaginylamino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide hydrochloride and 0.30 g (1.00 mmol) of 3-benzyloxycarbonylaminophenoxyacetic acid, 0.34 g of the title compound were obtained as a colorless powder, melting at 107°-117° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1594ba3e8e6e495c9513ad7386328805
来源数据集: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05629406
来源说明: uspto-grants-1997_05

反应 SMILES

Cl.[NH2:2][C@H:3]([C:8]([NH:10][C@@H:11]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C@H:12]([OH:27])[C:13]([N:15]1[CH2:26][CH2:25][CH2:24][C@H:16]1[C:17]([NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[O:14])=[O:9])[CH2:4][C:5](=[O:7])[NH2:6].[CH2:35]([O:42][C:43]([NH:45][C:46]1[CH:47]=[C:48]([CH:54]=[CH:55][CH:56]=1)[O:49][CH2:50][C:51](O)=[O:52])=[O:44])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH2:35]([O:42][C:43]([NH:45][C:46]1[CH:47]=[C:48]([CH:54]=[CH:55][CH:56]=1)[O:49][CH2:50][C:51]([NH:2][C@H:3]([C:8]([NH:10][C@@H:11]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C@H:12]([OH:27])[C:13]([N:15]1[CH2:26][CH2:25][CH2:24][C@H:16]1[C:17]([NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[O:14])=[O:9])[CH2:4][C:5](=[O:7])[NH2:6])=[O:52])=[O:44])[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1