2-(3-{[(Benzyloxy)carbonyl]amino}phenoxy)acetic acid → 1-{(2S,3S)-3-[N2-(3-Benzyloxycarbonylaminophenoxy)acetyl-L--asparaginyl]amino-2-hydroxy-4-phenylbutyryl}-N-t-butyl-L-prolinamide

Participants

Reaction Steps

Following a procedure similar to that described in Example 14, but using 0.45 g (0.91 mmol) of 1-[(2S,3S)-3-L-asparaginylamino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide hydrochloride and 0.30 g (1.00 mmol) of 3-benzyloxycarbonylaminophenoxyacetic acid, 0.34 g of the title compound were obtained as a colorless powder, melting at 107°-117° C.

Provenance & Evidence