HRID1780265

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19049815

6-Nitroquinoxaline-2-carboxylic acid

C9H5N3O4

结构：CC(C)(C)NC(=O)[C@@H]1CC(Cl)CN1C(=O)C(O)C(Cc1ccccc1)NC(=O)[C@@H](N)CC(N)=O.Cl

HCID67723033

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)NC(=O)[C@@H]1C[C@H](Cl)CN1C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1cnc2cc([N+](=O)[O-])ccc2n1

HCID86750833

未命名化合物

收率 29.6%

PROCEDURE

实验过程

Following a procedure similar to that described in Example 14, but using 490 mg (0.92 mmol) of 1-[3-(L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-4-chloro-N-t-butyl-L-prolinamide hydrochloride and 220 mg (1.01 mmol) of 6-nitroquinoxaline-2-carboxylic acid (prepared as described in Preparation 22), 190 mg of the title compound were obtained as a pale yellow powder, melting at 153°-156° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ff77e9df036441839247aff78b65bb12
来源数据集: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05629406
来源说明: uspto-grants-1997_05

反应 SMILES

Cl.[NH2:2][C@H:3]([C:8]([NH:10][CH:11]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH:12]([OH:28])[C:13]([N:15]1[CH2:26][CH:25]([Cl:27])[CH2:24][C@H:16]1[C:17]([NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[O:14])=[O:9])[CH2:4][C:5](=[O:7])[NH2:6].[N+:36]([C:39]1[CH:40]=[C:41]2[C:46](=[CH:47][CH:48]=1)[N:45]=[C:44]([C:49](O)=[O:50])[CH:43]=[N:42]2)([O-:38])=[O:37]>>[N+:36]([C:39]1[CH:40]=[C:41]2[C:46](=[CH:47][CH:48]=1)[N:45]=[C:44]([C:49]([NH:2][C@H:3]([C:8]([NH:10][C@@H:11]([CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[C@H:12]([OH:28])[C:13]([N:15]1[CH2:26][C@@H:25]([Cl:27])[CH2:24][C@H:16]1[C:17]([NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[O:14])=[O:9])[CH2:4][C:5](=[O:7])[NH2:6])=[O:50])[CH:43]=[N:42]2)([O-:38])=[O:37]