6-Nitroquinoxaline-2-carboxylic acid → (4S)-1-{(2S,3S)-3-[N2-(6-Nitro-2-quinoxalinecarbonyl)-L-asparaginyl]amino-2-hydroxy-4-phenylbutyryl}-4-chloro-N-t-butyl-L-prolinamide

Participants

Reaction Steps

Following a procedure similar to that described in Example 14, but using 490 mg (0.92 mmol) of 1-[3-(L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-4-chloro-N-t-butyl-L-prolinamide hydrochloride and 220 mg (1.01 mmol) of 6-nitroquinoxaline-2-carboxylic acid (prepared as described in Preparation 22), 190 mg of the title compound were obtained as a pale yellow powder, melting at 153°-156° C.

Provenance & Evidence