HCID 22872671, compound → HCID 22872662, compound

HRID 1780363Notes

Reaction equation

HRID 1780363 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([O:10][CH2:11][C@@H:12]2[CH2:15][CH2:14][N:13]2[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:6]=[N:7][C:8]=1[Cl:9])#[N:2].[H][H]>[Ni]>[NH2:2][CH2:1][C:3]1[CH:4]=[C:5]([O:10][CH2:11][C@@H:12]2[CH2:15][CH2:14][N:13]2[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:6]=[N:7][C:8]=1[Cl:9]

Participants

4

Reactant 2

HCID 22872671HCID 22872671, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22872662HCID 22872662, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

5-Cyano-6-chloro-3-(1-BOC-2-(S)-azetidinylmethoxy)pyridine (0.26 g, 0.80 mmol) from step 92a was stirred in the presence of Raney nickel (0.047 g, 0.80 mmol) under 1 atm of hydrogen at room temperature for 2 hours. The mixture was filtered, and the solvent was removed to give the title compound.

Workup

  1. filtrationThe mixture was filtered
  2. customthe solvent was removed

Sources & evidence

ORD record
ord-2c8c7e46d6c048c489098992cb0547bd
Source dataset
uspto-grants-1997_05
Patent number
US05629325

Reaction notes

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